Following the near fatal treatment received by four Botox patients recently, doctors are warning that the popular anti-wrinkle treatment can be harmful if not used properly. The cases involved the use of high concentration and unlicensed doses of botulinum toxin A. Based on data released three of the patients had between 21 to 43 times the lethal dose. Their lives were saved because they were able to access immediate medical attention.

The findings and warning were published in the current version of The Journal of the American Medical Association. The doctors noted that only botulinum toxin A which has been licensed should be used for cosmetic purposes.